Unbalanced Charge Distribution as a Determinant for Dependence of a Subset of Escherichia coli Membrane Proteins on the Membrane Insertase YidC
ABSTRACT Membrane proteins are involved in numerous essential cell processes, including transport, gene regulation, motility, and metabolism.To function properly, they must be inserted into the membrane and folded correctly.YidC, an essential protein in Escherichia coli with homologues in other bacteria, Archaea, mitochondria, and chloroplasts, fun